Dr. Joseph S. Takahashi, the Lloyd B. Sands Chair in Neuroscience at the University of Texas Southwestern Medical Center in Dallas, Texas, will give give a talk entitled, "Molecular Architecture of the Circadian Clock in Mammals" at the Virginia Tech Carilion Research Institute on Thursday, February 12, at 5:30 pm. A public reception will precede the event in the VTC Cafe at 5:00 p.m.
Dr. Takahashi will discuss the molecular basis of the circadian clock system, which originates at the level of cells and governs the daily cycles of behavior, physiology, and metabolism in organisms. The molecular clock is composed of a set of genes that are expressed on a 24-hour basis and feedback on themselves to generate a negative feedback loop. This molecular feedback loop also regulates the expression of thousands of genes on a daily basis to orchestrate many physiological pathways in the cell. In his talk, Dr. Takahashi will highlight the impact of the circadian clock system on metabolism and normal physiological function.