Many pathogenic viruses penetrate mucosal barriers and disseminate systemically in the infected host to cause disease. Mechanisms that guide viruses from sites of primary infection at mucosal surfaces to sites of secondary infection in target organs are not well understood. Mammalian reoviruses are tractable experimental models for studies of viral replication and pathogenesis. Dr. Dermody's laboratory has found that reovirus uses independent receptors to disseminate in the bloodstream and infect the central nervous system in mice. Remarkably, different components of the reovirus capsid are used to engage each receptor. This work identifies virus and host factors that govern viral systemic spread and resultant tissue injury.
A public reception will precede this event in the VTC Cafe at 5 p.m.
Terence S. Dermody, MD, is the director of pediatric infectious diseases, the director of the medical scientist training program, and a professor of pediatrics at Vanderbilt University in Nashville, Tennessee. His laboratory studies the molecular pathogenesis of mammalian reovirus and Chikungunya virus infections. The research encompasses several interrelated themes to better understand viral and cellular mediators of disease, including the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. The laboratory is also developing viral vectors for oncolytic and vaccine applications. Dr. Dermody earned his medical degree from Columbia University and completed an internship and his residency at Presbyterian Hospital in New York City.
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